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In a placebo-controlled trial in normal volunteers, administration of sertraline hydrochloride for 22 days (including 200 mg/day for the final 13 days) caused a statistically significant 16% decrease from baseline in the clearance of tolbutamide following an intravenous 1000 mg dose. Sertraline hydrochloride administration did not noticeably change either the plasma protein binding or the apparent volume of distribution of tolbutamide, suggesting that the decreased clearance was due to a change in the metabolism of the drug. The clinical significance of this decrease in tolbutamide clearance is unknown.
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SERTRALINE (Zoloft®) is an antidepressant. It helps to improve a depressed person's mood. Sertraline can also help people with an obsessive compulsive disorder, panic attacks, post-trauma stress, or social anxiety. Sertraline may also be prescribed for other purposes, like premenstrual dysphoric disorder (PMDD), a severe type of premenstrual syndrome. Generic sertraline tablets are available.
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sertraline (zoloft) article
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